The Ophthalmic Photographer’s Role in Recording the Morphological Changes of Ebola-Specific Retinal Lesions using Spectral Domain Optical Coherence Tomography

Denise Cunningham, MS, MEd, FOPS

Chief, Imaging Services Section
National Eye Institute, National Institutes of Health
US Department of Health and Human Resources
Bethesda, MD USA

Purpose: To describe a variety useful imaging modalities for identifying Ebola-specific retinal abnormalities and demonstrate the advantage of employing spectral domain optical coherence tomography longitudinally for follow-up.

Methods: A confocal scanning laser with multimodal imaging capability was used to document posterior segment ocular pathology discovered in survivors of Ebola virus disease (EVD). Disease-specific lesions, with the characteristic angulated appearance and dark surround, were identified in multi-color, infrared, blue reflectance, and fundus autofluorescence images. Cross-sectional three-dimensional views of these lesions were obtained using the instrument’s spectral domain optical coherence tomography (SD-OCT) module.

Results: A comprehensive ophthalmic photographer performed baseline and three-year follow-up SD-OCT scans on 10 Ebola-specific lesions found in 8 eyes of 7 EVD survivors by. Scans acquired of the Ebola-specific lesions during the initial image capture sessions demonstrated disruption of the retinal architecture and shadowing, or loss, of the inner segment ellipsoid and cone interdigitation zones. At the three-year mark, SD-OCT scans of 9/10 lesions exhibited remodeling of the inner retinal layers and reconstitution of the hyperreflective bands of the outer retina.

Conclusion: Ophthalmic imaging professionals play a crucial role in the documentation and discovery of the ocular manifestations of disease.

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ICOP 2023
Maaike van Zuilen

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